barw Judi Clinical Journal 3105-4102 1 2 2025 11 18 Clinicopathological Profile of Malignant Tumors at a Tertiary Center in Iraq: A Five-Year Analysis 89 98 10.70955/JCJ.2025.12 eng Fahmi H. Kakamad College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Iraq 0000-0002-2124-9580 Berun A. Abdalla Scientific Affairs Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Dahat A. Hussein Laboratory Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Fakher Abdullah Kscien Organization for Scientific Research (Middle East Office), Hamdi Street, Azadi Mall, Sulaymaniyah, Iraq. Ayman M. Mustafa Scientific Affairs Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Sabah J. Hasan Scientific Affairs Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Mohammed S. Ezzat Operation Theater Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Harem S. Amin Pharmacy Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Lanya Q. Rashid Operation Theater Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Muhammad A. Khdir Pharmacy Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Danyar G. HamaSaeed Pharmacy Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Hussein H. Rasul Pharmacy Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq Akam R. Ahmed Operation Theater Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq 2025 08 18 Introduction: Cancer incidence and mortality are increasing worldwide, disproportionately affecting low- and middle-income countries due to limited healthcare access. This study aims to analyze the prevalence and clinicopathological characteristics of cancers diagnosed at a tertiary care center, offering crucial data to inform regional cancer control efforts. Methods: This retrospective study was conducted at a single tertiary center, analyzing histopathological reports from January 2020 to January 2025. Data were collected from digital and physical archives by a trained team, including only confirmed malignant diagnoses. Variables extracted included patient demographics, cancer types, tumor characteristics, and procedure details. Data integrity was ensured through double-entry and expert review. Statistical analysis using SPSS 27.0 summarized categorical variables as frequencies, percentages and continuous variables as means or medians. Results: A total of 9,375 cases were analyzed (median age 48 years), with females comprising 75.74% (7,101 cases). The age-standardized incidence rate was 82.20 per 100,000. Head and neck cancers accounted for 2,903 cases (30.97%), primarily thyroid (2,208 cases), followed by thoracic malignant tumors with 2,556 cases (27.26%). Invasive ductal carcinoma was most frequent cancer type (2,392 cases, 25.5%). Larger tumors correlated significantly with positive margins and lymph node involvement (p < 0.05). Conclusion: The study highlights a unique cancer profile, with younger age at diagnosis and higher rates of head, neck, and thyroid cancers. These findings underscore the need for targeted screening and prevention strategies adapted to regional healthcare systems.